| 摘要 |
<p>This invention relates to the synthesis of submicron monetite powders to be used as highly soluble and resorbable bone substitute materials. Monetite (CaHPO4) powders were prepared by reacting precipitated and submicron calcium carbonate powders together with phosphoric acid in a medium of pure ethanol. The solutions did not contain any water. Monetite synthesis reaction was performed at room temperature. Monetite synthesis reaction was typically completed in 3 hours. The obtained monetite powders were submicron and consisting of nano sheets of monetite stacked together. The mildly acidic monetite powders were aged in a calcium-containing saline solution at 37oC for 6 days to produce neutral calcium phosphate powders with nanosize particles. The calcium-containing saline solution contained 142 mM Na+, 5 mM K+ and 50 mM Ca2+ ions.</p> |
