发明名称 |
INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF |
摘要 |
The present invention provides novel methods for modulating Th l 7-mediated immune responses using aminoacyl tRNA synthetase inhibitors. Inhibition of aminoacyl tRNA synthetase inhibitors activates an amino acid starvation response (AAR) and can produce beneficial therapeutic effects. In some embodiments, aminoacyl tRNA synthetase inhibitors are used to treat disorders such as autoimmune diseases, graft rejection, infections, fibrosis, and inflammatory diseases. |
申请公布号 |
WO2010096170(A2) |
申请公布日期 |
2010.08.26 |
申请号 |
WO2010US00460 |
申请日期 |
2010.02.17 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;WHITMAN, MALCOLM;KELLER, TRACY |
发明人 |
WHITMAN, MALCOLM;KELLER, TRACY |
分类号 |
A61K35/26;A61K31/52;C12N5/0783;A61P37/00;A61P37/02;C07D487/04 |
主分类号 |
A61K35/26 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|