发明名称 |
Sustained-release composition and method for producing the same |
摘要 |
Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt% to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drag sustained-release over a long period of time, and method for producing the same. |
申请公布号 |
ZA200903644(B) |
申请公布日期 |
2010.08.25 |
申请号 |
ZA20090003644 |
申请日期 |
2007.12.17 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
FUTO, TOMOMICHI;SAITO, KAZUHIRO;HOSHINO, TETSUO;HORI, MASUHISA |
分类号 |
A61K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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