发明名称 |
HDAC INHIBITORS AND HORMONE TARGETED DRUGS FOR THE TREATMENT OF CANCER |
摘要 |
The present invention relates to the methods of treating endocrine-regulated cancers, including hormone resistant cancers, for example. More specifically, the present invention relates to a method of increasing the sensitivity of hormone resistant cancers to hormonal therapeutic agents. In particular embodiments, the present invention concerns delivery of a histone deacetylase inhibitor, which is MS-275 and a hormone targeted drug to an individual with cancer. In specific embodiments, the histone deacetylase inhibitor and the hormone targeted drug act synergistically to treat the cancer, including by overcoming resistance to a cancer therapy. |
申请公布号 |
EP2167090(A4) |
申请公布日期 |
2010.08.25 |
申请号 |
EP20080770366 |
申请日期 |
2008.06.06 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
BRODIE, ANGELA;NJAR, VINCENT, C.O.;SABNIS, GAURI;GEDIYA, LALJI |
分类号 |
A61K31/495;A61K31/10;A61K31/196;A61K31/4196;A61K31/44;C07C259/10;C07D215/20;C07D233/54 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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