Substituted heteroaryl pyridopyrimidone derivatives

摘要

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof :
wherein:
Y represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C 1-2 alkyl group and a hydrogen atom;
Z represents a bond, an oxygen atom, a nitrogen atom, a sulphur atom, a methylene group optionally substituted by one or two groups chosen from a C 1-6 alkyl group, a hydroxyl group, a C 1-6 alkoxy group, a C 1-2 perhalogenated alkyl group or an amino group;
R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring;
R2 represents a 4-15 membered heterocyclic group , R3 represents a hydrogen atom, a C 1-6 alkyl group or a halogen atom; R4 and R5 represent, each independently, a hydrogen atom, a C 1-6 alkyl group, optionally substituted by 1 to 4 substituents selected from a halogen atom, a phenyl group, a hydroxyl group or a C 1-6 alkoxy group; R6 represents a hydrogen atom, a C 1-6 alkyl group ; a cycloalkyl group, or a halogen atom; R7 represents a hydrogen atom or a C 1-6 alkyl group;
n represents 0 to 3; m represents 0 to 1; o represents 0 to 2; in the form of a free base or of an addition salt with an acid. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3², such as Alzheimer disease.