Cytokine ligand for the treatment of asthma and airway hyper-responsiveness
摘要
There is provided the use of a polypeptide for the manufacture of a medicament for up-regulating IL-13RA2 gene expression in a mammal, wherein the polypeptide comprises a sequence of amino acid residues that is at least 90% identical to the sequence of amino acid residues of a polypeptide selected from: (a) a polypeptide comprising the amino acid sequence from residues 38 (Val) to 152 (Leu) as shown in SEQ ID NO:2; (b) a polypeptide comprising the amino acid sequence from residues 27 (Leu) to 164 (Thr) as shown in SEQ ID NO:2; (c) a polypeptide comprising the amino acid sequence from residues 24 (Ser) to 164 (Thr) as shown in SEQ ID NO:2; and (d) a polypeptide comprising the amino acid sequence from residues 1 (Met) to 164 (Thr) as shown in SEQ ID NO:2.
申请公布号
EP1961811(B1)
申请公布日期
2010.08.25
申请号
EP20080102636
申请日期
2003.01.21
申请人
ZYMOGENETICS, INC.
发明人
SPRECHER, CINDY, A.;KUIJPER, JOSEPH L.;DASOVICH, MARIA M.;GRANT, FRANCIS, J.;HAMMOND, ANGELA K.;NOVAK, JULIA E.;GROSS, JANE A.;DILLON, STACEY, R.