MUTANT NUCLEIC ACID RELATED TO CHRONIC MYELOPROLIFERATIVE DISORDER, AND METHOD OF EVALUATING CHRONIC MYELOPROLIFERATIVE DISORDER

摘要

A new mutant gene related to the onset of CMPD, particularly, the new mutant gene related to the onset of CMPD in patients who develop CMPD despite of JAK2 V617F -negative, and an evaluation method for evaluating CMPD are provided. By detecting the following mutation in a JAK2 gene or an EPOR gene in a biological sample of human origin, the possibility of CMPD is evaluated. (a) a mutation from G at the 2116 th position to A in a base sequence of SEQ ID NO: 1, (b) a deletion of a nucleotide residue from the 2121 st to 2126 th position in a base sequence of SEQ ID NO: 1, (c) a mutation from C at the 1641 st position to G in a base sequence of SEQ ID NO: 4.