发明名称 |
Agents for magnetic imaging method |
摘要 |
The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer, m is an integer and p is an integer. These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.
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申请公布号 |
US7780952(B2) |
申请公布日期 |
2010.08.24 |
申请号 |
US20040516781 |
申请日期 |
2004.12.03 |
申请人 |
BRACCO IMAGING SPA |
发明人 |
AIME SILVIO;MAINERO VALENTINA;GENINATTI SIMONETTA CHIRICH;CABELLA CLAUDIA |
分类号 |
A61B5/055;G01R33/28;A61K41/00;A61K49/00;A61K49/08;C07C237/10;C07C237/12;C07C271/22;C07C279/12;C07C279/14;C07D257/02;C07F5/00;C07H5/06 |
主分类号 |
A61B5/055 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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