发明名称 |
POLYNUCLEOTIDE PARTICIPATING IN RHEUMATOID ARTHRITIS AND UTILIZATION OF THE SAME |
摘要 |
Analysis is made on the DNA methylation of the region (including a promoter region) upstream from the initiation point of a rheumatoid arthritis-associated gene DR3 in human genome. As a result, it is found out that an allele-specific methylation occurs in a CpG sequence located about -380 to -180 bp upstream from initiation point (ATG) of the gene DR3. It is further found out that the CpG sequences downstream therefrom of the genes DR3 originating in healthy subjects are all in the unmethylated state, while methylated and unmethylated sequences are both observed in the genes DR3 originating in RA patients.
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申请公布号 |
CA2557368(C) |
申请公布日期 |
2010.08.24 |
申请号 |
CA20042557368 |
申请日期 |
2004.11.25 |
申请人 |
SHIOZAWA, SHUNICHI |
发明人 |
SHIOZAWA, SHUNICHI;OSAWA, KAYO;TAKAMI, NOZOMI;HASHIRAMOTO, AKIRA;MIURA, YASUSHI |
分类号 |
C12N15/09;A61K31/7115;A61K48/00;A61P19/02;A61P29/00;A61P43/00;C12Q1/68;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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