SULFONAMIDE-CONTAINING INDOLE COMPOUND

摘要

<P>PROBLEM TO BE SOLVED: To create a new angiogenesis inhibitor and provide an antitumor agent which shows high safety as compared with conventional antitumor agents, having a sure effect and is capable of being administered for a long period. Ž<P>SOLUTION: There are provided indole compounds or pharmacologically acceptable salt or hydrates thereof selected from the following compounds. The compounds are such as (1) 6-chloro-N-(3-cyano-4-methyl-1H-indole-7-yl)-3-pyridine sulfonamide, (2) N-(3-bromo-5-methyl-1H-indole-7-yl)-4-sulfamoylbenzenesulfonamide, (3) N-(3-bromo-5-methyl-1H-indole-7-yl)-3-cyanobenzene sulfonamide, (4) N-(4-bromo-1H-indole-7-yl)-4-cyanobenzene sulfonamide, (5) 6-amino-N-(4-chloro-1H-indole-7-yl)-3-pyridine sulfonamide, (6) N-(3-bromo-5-methyl-1H-indole-7-yl)-5-cyano-2-thiophenesulfoamide, (7) 2-amino-N-(4-bromo-3-chloro-1H-indole-7-yl)-5-pyrimidine sulfonamide. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž