发明名称 |
THERMAL INACTIVATION OF ROTAVIRUS |
摘要 |
Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.
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申请公布号 |
US2010209455(A1) |
申请公布日期 |
2010.08.19 |
申请号 |
US20080676490 |
申请日期 |
2008.09.04 |
申请人 |
JIANG BAOMING;GLASS ROGER I;SALUZZO JEAN-FRANCOIS |
发明人 |
JIANG BAOMING;GLASS ROGER I.;SALUZZO JEAN-FRANCOIS |
分类号 |
A61K39/15;A61P31/12;C12N7/04 |
主分类号 |
A61K39/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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