发明名称 |
ACE2 INHIBITORS FOR REDUCING GASTROINTESTINAL ADVERSE EFFECTS OF CYTOTOXIC AGENTS |
摘要 |
<p>A method for moderating a gastrointestinal adverse effect induced by at least one cytotoxic agent, for example ionizing radiation and/or at least one chemotherapeutic agent, in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor or a compound selected from (S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)- 3H-imidazol-4-yl]-ethylamino]-4-methylpentanoic acid (ORElOOl), pharmaceutically acceptable salts thereof and prodrugs thereof. A method for treating a cancerous condition in a subject comprises administering to the subject (a) at least one cytotoxic anticancer agent, for example ionizing radiation and/or at least one chemotherapeutic agent; and (b) an ACE2 inhibitor or a compound selected from ORE1001, pharmaceutically acceptable salts thereof and prodrugs thereof in an amount effective to moderate a gastrointestinal adverse effect induced by the anticancer agent.</p> |
申请公布号 |
WO2010093804(A1) |
申请公布日期 |
2010.08.19 |
申请号 |
WO2010US23915 |
申请日期 |
2010.02.11 |
申请人 |
ORE PHARMACEUTICALS, INC.;DONAHUE, STEPHEN, R.;BYRNES, JOHN, J. |
发明人 |
DONAHUE, STEPHEN, R.;BYRNES, JOHN, J. |
分类号 |
A61K31/4164;A61K31/00;A61P1/00 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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