摘要 |
The present invention relates to heterocyclic derivatives of formula I useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, like, e.g. pain., (I) or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: ring Z is a thiazole or thiadiazole optionally substituted with 0-2 occurrences of R; V is CH2, NH, O, or S; and R, R1, R2, and R3 are hydrogen, C1-C6 aliphatic, aryl, C3-C8 cycloaliphatic, halo, CN, NO2, CF3, OCF3, OH, NH2, NH(C1-C6 aliphatic), N(C1-C6 aliphatic) 2, COOH, COO(C1 -C6 aliphatic), O(C1-C6 aliphatic), CHF2, or CH2F. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;STAMOS, DEAN;MARTINBOROUGH, ESTHER;NEUBERT, TIMOTHY;NUMA, MEHDI, MICHEL DJAMEL;WHITNEY, TARA;ZIMMERMANN, NICOLE;KAWATKAR, AARTI, SAMEER |
发明人 |
STAMOS, DEAN;MARTINBOROUGH, ESTHER;NEUBERT, TIMOTHY;NUMA, MEHDI, MICHEL DJAMEL;WHITNEY, TARA;ZIMMERMANN, NICOLE;KAWATKAR, AARTI, SAMEER |