| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a storage-stable pharmaceutical preparation containing oxycodone and naloxone in pain therapy, which releases active agents thereof in a sustained, independent and invariant manner. <P>SOLUTION: The preparation is characterized in that oxycodone is present in excess referred to the unit dosage amount of naloxone, that a diffusion matrix of the preparation comprises at least ethylcellulose and at least one fatty alcohol as the components that essentially influence the release behavior of the active compounds, and that the preparation does not comprise relevant parts of alkaline and/or water-swellable substance, particularly derivatives of acrylic acid and/or hydroxyalkyl celluloses. <P>COPYRIGHT: (C)2010,JPO&INPIT |
