发明名称 |
SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS |
摘要 |
The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
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申请公布号 |
US2010210594(A1) |
申请公布日期 |
2010.08.19 |
申请号 |
US20080669978 |
申请日期 |
2008.07.25 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
WAGNER HOLGER;LANGKOPF ELKE;ECKHARDT MATTHIAS;STREICHER RUEDIGER;SCHOELCH CORINNA;SCHULER-METZ ANNETTE;PAUTSCH ALEXANDER |
分类号 |
A61K31/675;A61P3/10;C07F9/572;C07F9/645;C07F9/6503;C07F9/6509;C07F9/6512;C07F9/6521;C07F9/6533;C07F9/6544 |
主分类号 |
A61K31/675 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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