发明名称 |
POLYMERIC IMMOBILIZATION MATRIX FOR LIVE-CELL BIOSENSORS |
摘要 |
<p>The present invention relates to a portable device for the detection of analytes, in particular toxic substances, comprising at least a whole-cell biosensor with cells immobilized onto a transparent and inert matrix that allows the maintenance of cell vitality. The matrix comprises a mixture of collagen and/or its enzyme degradation derivatives, a proteoglycan and a mixture of vinyl polymer and an optionally modified polysiloxane, and an orthosilicate. The biosensor can be a genetically modified cell that expresses luciferase as reporter gene.</p> |
申请公布号 |
CA2752671(A1) |
申请公布日期 |
2010.08.19 |
申请号 |
CA20102752671 |
申请日期 |
2010.02.11 |
申请人 |
ALMA MATER STUDIORUM UNIVERSITA DI BOLOGNA |
发明人 |
MICHELINI, ELISA;RODA, ALDO;DOLCI, LUISA STELLA;CEVENINI, LUCA;MEZZANOTTE, LAURA |
分类号 |
C12Q1/02;G01N33/50;G01N33/543 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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