发明名称 |
CONJUGATES OF 19F MR IMAGING TRACERS FOR USE IN MULTI-CHROMIC MRI IMAGING |
摘要 |
Compositions for producing multi-chromic ("color") magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a 19F imaging tracer (19FIT), conjugated with a magnetic signal modulator, such as a paramagnetic functional group or a paramagnetic ion. The 19FIT and the signal modulator (M) are joined covalently by a chelator such as DOTA, forming a nanometer-sized fluorinated paramagnetic complex 19FIT-DOTA-M. Other signal emitters, such as 31P imaging tracer (31PIT), can also be modulated using this strategy (i.e., 31PIT-DOTA-M) to generate multi-chromic 31P MRI or MRS. |
申请公布号 |
WO2010056590(A3) |
申请公布日期 |
2010.08.19 |
申请号 |
WO2009US63381 |
申请日期 |
2009.11.05 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;UNIVERSITY OF MARYLAND, COLLEGE PARK;YU, YIHUA, BRUCE;JIANG, ZHONG-XING |
发明人 |
YU, YIHUA, BRUCE;JIANG, ZHONG-XING |
分类号 |
A61K49/06 |
主分类号 |
A61K49/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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