HETERO RING DERIVATIVE

摘要

Disclosed is a novel excellent prophylactic or therapeutic method for rejections in various types of organ transplantation, allergic diseases, autoimmune diseases, hematologic tumors and others, which relies on a selective inhibitory activity on PI3Kd and/or an inhibitory activity on the production of IL-2 and/or an inhibitory activity on the proliferation of B cells (including an inhibitory activity on the activation of B cells). It is found that a tri-substituted triazine derivative or a tri-substituted pyrimidine derivative has a selective inhibitory activity on PI3Kd and/or an inhibitory activity on the production of IL-2 and/or an inhibitory activity on the proliferation of B cells (including an inhibitory activity on the activation of B cells) and can be used as a prophylactic or therapeutic agent for rejections in various types of organ transplantation, allergic diseases (e.g., asthma, atopic dermatitis), autoimmune diseases (e.g., rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn diseases, systemic lupus erythematosus), hematologic tumors (e.g., leukemia) and others.