发明名称 |
METHOD FOR AMPLIFYING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND |
摘要 |
An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided. A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof. |
申请公布号 |
EP2218716(A1) |
申请公布日期 |
2010.08.18 |
申请号 |
EP20080858085 |
申请日期 |
2008.12.06 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD.;REPROCELL INCORPORATED |
发明人 |
NISHINO, TAITO;ISHIWATA, NORIHISA;MIYAJI, KATSUAKI;IWAMOTO, SHUNSUKE;ASAI, YASUYUKI;YUI, MAKIKO |
分类号 |
C07D333/38;A61K31/381;A61K31/4155;A61K31/4178;A61K31/4196;A61K31/422;A61K31/427;A61K31/4436;A61K31/497;A61K31/506;A61K31/5377;A61K35/14;A61K35/18;A61K38/00;A61K48/00;A61P7/04;A61P7/06;A61P9/10;C07D231/18 |
主分类号 |
C07D333/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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