TREATING STROKE AND OTHER DISEASES WITHOUT INHIBITING N-TYPE CALCIUM CHANNELS
摘要
<p>The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide of an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases.</p>
申请公布号
EP2120987(A4)
申请公布日期
2010.08.18
申请号
EP20080726313
申请日期
2008.02.29
申请人
ARBOR VITA CORPORATION;NONO, INC.
发明人
BELMARES, MICHAEL, P.;GARMAN, JONATHAN, DAVID;LU, PETER, S.;SALTER, MICHAEL, W.;TYMIANSKI, MICHAEL