发明名称 |
Methods for decreasing risk of complications of prematurity using IGF-I and its analogs |
摘要 |
In one aspect of the present invention there is provided a method for determining the risk of developing a complication of preterm birth in a patient born before 40 weeks of gestation or weighing 10% less than the average for the patient's gestational age. The method involves measuring serum IGF-I and/or IGF-I binding protein levels after birth of the patient to obtain an IGF-I or IGF-I binding protein level; and correlating said IGF-I or IGF-I binding protein level with an in utero baseline level of IGF-I or IGF-I binding protein based on gestational age matched mean levels in utero, wherein an IGF-I or IGF-I binding protein level below the mean gestational age in utero level indicates the patient is at an increased risk of developing a complication of preterm birth. The complications of preterm birth include retinopathy of prematurity, developmental delay, mental retardation, bronchopulmonary dysplasia, and intraventricular hemorrhage. Methods for treating/preventing and reducing the risk of complications of preterm birth using IGF-I and ins analogs are also provided.
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申请公布号 |
US7776820(B2) |
申请公布日期 |
2010.08.17 |
申请号 |
US20060521209 |
申请日期 |
2006.09.14 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
SMITH LOIS E. H.;HELLSTROEM ANN |
分类号 |
A61K38/00;G01N33/68;A61J1/14;A61K;A61K38/28;A61K38/30;A61P1/04;A61P3/00;A61P3/10;A61P5/00;A61P9/00;A61P11/00;A61P25/18;A61P27/02;A61P43/00 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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