发明名称 |
Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
摘要 |
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
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申请公布号 |
US7777017(B2) |
申请公布日期 |
2010.08.17 |
申请号 |
US20070724040 |
申请日期 |
2007.03.13 |
申请人 |
BIOSYNEXUS INCORPORATED |
发明人 |
STINSON JEFFREY R.;SCHUMAN RICHARD F.;MOND JAMES JACOB;LEES ANDREW;FISCHER GERALD WALTER |
分类号 |
C07H21/04;A61K39/395;C07K16/00;C07K16/12;C12N15/00;C12P21/04;C12P21/08 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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