| 摘要 |
There is provided a compound which can be used for therapy of diseases in which 11&bgr;-hydroxysteroid dehydrogenase type 1 (11&bgr;-HSD1) participates, in particular diabetes, insulin resistance. It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11&bgr;-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
|
