6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D] AZEPINES AS 5-HT2C RECEPTOR AGONISTS

摘要

THE PRESENT INVENTION PROVIDES 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H- BENZO[d]AZEPINES OF FORMULA I AS SELECTIVE 5-HT₂c RECEPTOR AGONISTS FOR THE TREATMENT OF 5-HT₂c ASSOCIATED DISORDERS INCLUDING OBESITY, OBSESSIVE/COMPULSIVE DISORDER, DEPRESSION, AND ANXIETY: WHERE: R⁶ IS–C=C-R10, -O-R¹², -S-R14, OR -NR²⁴R25; AND OTHER SUBSTITUENTS ARE AS DEFINED IN THE SPECIFICATION.