VERFAHREN ZUR IN-VITRO-ERKENNUNG VON ANORMALER MAGEN-DYSPLASIE

摘要

The present invention provides a method for in vitro detection of malignant potential of dysplasia by aberrant methylation of p16 CpG islands, composing extraction of genomic DNA from tissue or body fluid samples, analysis of methylation status of p16 CpG islands, evaluation of malignant potential of testing tissues. The present invention also provides a group of artificial sequences of p16 CpG island with or without methylation.