| 发明名称 |
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR MODULATION UND ZUM NACHWEIS VON WISP-AKTIVITÄT |
| 摘要 |
<p>Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of IIAS2, IIA, CD44 or RIIAMM by native human WISP-1 polypeptide in at least one type of cells or pathological conditions associated with native WISP-1 polypeptides.</p> |
| 申请公布号 |
AT476447(T) |
申请公布日期 |
2010.08.15 |
| 申请号 |
AT20030739341T |
申请日期 |
2003.06.28 |
| 申请人 |
GENENTECH, INC. |
发明人 |
DESNOYER, LUC;FILVAROFF, ELLEN |
| 分类号 |
C07K16/28;A61K39/00;A61K39/395;C07K14/47;C07K16/22;C07K16/30;C12N15/12;C12P21/08 |
主分类号 |
C07K16/28 |
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