发明名称 |
PROCESS FOR THE PREPARATION OF OPTICALLY PURE R (-) SALBUTAMOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
摘要 |
A process for the preparation of optically pure R (−) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1 to C4 branched or normal chain alcohol for dissolution of the racemic mixture and resolving agent and purification of the 4-nitro tartranilic acid salt of R (−) salbutamol. 4-nitro tartranilic acid salt of R (−) salbutamol is converted into formic acid salt of R(−) 4-benzyl salbutamol followed by basification and debenzylation to form optically pure R(−) salbutamol. Optically pure (R)-salbutamol is obtained in good yield and high purity. The optically pure R(−)salbutamol is optionally converted into pharmaceutically acceptable salts.
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申请公布号 |
US2010204516(A1) |
申请公布日期 |
2010.08.12 |
申请号 |
US20100374318 |
申请日期 |
2010.03.02 |
申请人 |
AARTI HEALTHCARE LIMITED |
发明人 |
DESAI PARIMAL;SALVI NARENDRA;PATRAVALE BHARATKUMAR;SEETHARAMAN SUBRAMANIAN;PATIL DILIP;GHOGARE KHANDU |
分类号 |
C07B57/00;C07C215/60 |
主分类号 |
C07B57/00 |
代理机构 |
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