NOVEL DIAGNOSTIC MARKER FOR TYPE 1 DIABETES MELLITUS

摘要

The present invention relates to a novel diagnostic marker for type 1 diabetes mellitus, and more specifically to a diagnostic composition for type 1 diabetes mellitus containing aminoacyl-tRNA synthetase or an antibody therefor as an effective component, application of the aminoacyl-tRNA synthetase in the preparation of a diagnostic agent for type 1 diabetes mellitus, and a diagnosis method for type 1 diabetes mellitus that involves the detection of anti-Alanine tRNA synthetase antibodies, anti-Glycine tRNA synthetase antibodies, anti-Asparagine tRNA synthetase antibodies and anti-Tryptophan tRNA synthetase antibodies from a sample of an object. The composition, diagnosis kit and diagnosis method of the present invention facilitate the diagnosis of type 1 diabetes mellitus from the specimen of a patient, and thus may be used for early diagnosis and confirmation of type 1 diabetes mellitus.