发明名称 |
ACECLOFENAC-CONTAINING CONTROLLED-RELEASE ORAL DRUG PREPARATIONS AND THEIR MANUFACTURING PROCESS |
摘要 |
<p>Disclosed herein are single-layer and double-layer tablets, which release aceclofenac in a controlledmanner so as to achieve ideal drug release close to a straight line. Also, the tablets promote drug absorption in the stomach by controlling pH, contain aceclofenac with improved stability and haveboth immediate-release properties and sustained-release properties. Specifically, provided is an aceclofenac sustained-release tablet which is composed of an immediate-release layer containing aceclofenac, a water-soluble additive, a pH-controlling agent, a disintegrant, a filler and a lubricant and of a sustained-release layer containing aceclofenac, a release-controlling polymer, an oil-soluble surfactant, a filler and a lubricant, wherein the pH-controlling agent is sodium hydrogen carbonate, and the release-controlling polymer is a mixture of hydroxypropylmethylcellulose and carbomer.</p> |
申请公布号 |
WO2010090371(A1) |
申请公布日期 |
2010.08.12 |
申请号 |
WO2009KR02251 |
申请日期 |
2009.04.29 |
申请人 |
KOREA UNITED PHARM, INC;LEE, BEOM-JIN;CHOI, YOUN-WOONG;MIN, BYUNG-GU;AN, SEUNG-HO |
发明人 |
LEE, BEOM-JIN;CHOI, YOUN-WOONG;MIN, BYUNG-GU;AN, SEUNG-HO |
分类号 |
A61K9/24;A61K9/22;A61K9/54;A61K47/30 |
主分类号 |
A61K9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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