NOVEL VANCOMYCIN-AMINOQUINOLINE HYBRID MOLECULES THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

摘要

The present invention relates to novel vancomycin-aminoquinoline hybrid molecules designated "vancomyquines®", preparation thereof and application thereof in therapeutics. The present invention notably relates to novel hybrid molecules in which vancomycin is bound covalently to substituted 4-aminoquinolines. The present invention describes the preparation of these hybrid molecules designated "vancomyquines®" corresponding to formula (I) as well as their therapeutic use as an antibacterial agent.