发明名称 |
CYCLIC INHIBITORS OF 11.BETA.HYDROXYSTEROID DEHYDROGENASE 1 |
摘要 |
This invention relates to novel compounds of the Formula Formulas (I), (Ia1-20), (Ib1-20), (Ic1-20), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11ß-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
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申请公布号 |
CA2744946(A1) |
申请公布日期 |
2010.08.12 |
申请号 |
CA20102744946 |
申请日期 |
2010.02.03 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;ECKHARDT, MATTHIAS |
发明人 |
HIMMELSBACH, FRANK;ECKHARDT, MATTHIAS |
分类号 |
C07D413/10;A61K31/5355;A61P3/00;C07D417/10 |
主分类号 |
C07D413/10 |
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