| 摘要 |
<p>The invention provides method of distinguishing between long-term and short-term survivors of pancreatic cancer, comprising:
detecting the level of expression in a tissue sample of one or more miR gene products selected from a group of miR gene products consisting of miR-452, miR-105, miR-127, miR-518a-2, miR-187 and miR-30a-3p; or a group of miRs gene products consisting of: miR-452, miR-105, miR-127, miR-518a-2, miR-187 and miR-30a-3p; or one or more miR gene products selected from a group of miR gene products consisting of miR-452, miR-105, miR-127, miR-518a-2, miR-187 and miR-30a-3p in combination with miR-127; or a a group of miRs gene products consising of: miR-452, miR-105, miR-127, miR-518a-2, miR-187, miR-30a-3p and miR-127;
wherein differential expression in the levels of the one or more miR gene products, relative to the levels of the corresponding miR gene products in a control sample, is indicative of long-term survivors of pancreatic cancer The invention provides kits for use in differentiating pancreatic cancer from at least one of normal pancreatic tissue and chronic pancreatitis in a human patient, said kit comprising one or more solid supports having attached thereto one or more oligonucleotides complementary to miR gene products.</p> |
