EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
摘要
The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-ß-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.
申请公布号
WO2010033906(A3)
申请公布日期
2010.08.12
申请号
WO2009US57669
申请日期
2009.09.21
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;ICHIDA, JUSTIN;BLANCHARD, JOEL;LAM, KELVIN;RUBIN, LEE;EGGAN, KEVIN
发明人
ICHIDA, JUSTIN;BLANCHARD, JOEL;LAM, KELVIN;RUBIN, LEE;EGGAN, KEVIN