发明名称 |
METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS |
摘要 |
The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal &bgr;-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a &bgr;-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing &bgr;-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a &bgr;-methyl-thiazolidine residue to a &bgr;-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins.
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申请公布号 |
US2010204449(A1) |
申请公布日期 |
2010.08.12 |
申请号 |
US20080676332 |
申请日期 |
2008.08.28 |
申请人 |
DONG ZHENG XIN;KIM SUN H |
发明人 |
DONG ZHENG XIN;KIM SUN H. |
分类号 |
C07K1/107;C07C229/02;C07K2/00;C07K14/00 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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