发明名称 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS
摘要 The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal &bgr;-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a &bgr;-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing &bgr;-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a &bgr;-methyl-thiazolidine residue to a &bgr;-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins.
申请公布号 US2010204449(A1) 申请公布日期 2010.08.12
申请号 US20080676332 申请日期 2008.08.28
申请人 DONG ZHENG XIN;KIM SUN H 发明人 DONG ZHENG XIN;KIM SUN H.
分类号 C07K1/107;C07C229/02;C07K2/00;C07K14/00 主分类号 C07K1/107
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