发明名称 |
Use of statins in the prevention and treatment of radiation injury and other disorders associated with reduced endothelial thrombomodulin |
摘要 |
The present invention discloses statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) consistently and significantly increased endothelial cell thrombomodulin protein and functional activity. Statins also abrogated the downregulation of thrombomodulin that occurs in response to radiation injury. These results indicate that preserving or restoring endothelial thrombomodulin expression and function by statins may be useful in a variety of disorders associated with widespread endothelial dysfunction such as sepsis, adult respiratory distress syndrome, and normal tissue radiation injury.
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申请公布号 |
US2010204254(A1) |
申请公布日期 |
2010.08.12 |
申请号 |
US20100657915 |
申请日期 |
2010.01.29 |
申请人 |
THE UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES |
发明人 |
HAUER-JENSEN MARTIN K.;FINK LOUIS M.;MEHTA JAWAHAR LAL;WANG JUNRU;JOSEPH JACOB |
分类号 |
A61K31/505;A61K;A61K31/22;A61K31/225;A61K31/366;A61K31/40;A61K31/404 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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