COMPOSITION FOR PREVENTION OR TREATMENT OF HEART FAILURE

摘要

The present invention relates to a composition for the prevention or treatment of heart failure, and to a method for screening a therapeutic agent for heart failure. The present invention is the first to disclose that the administration of a PKC? inhibitor exhibits cardiotonic effects that increase myocardial contractility, and thus it may contribute substantially to the prevention or treatment of heart failure. In addition, the present invention acts by a mechanism that changes the calcium sensitivity within myocardial muscle cells, unlike the existing principle of cardiotonics, and thus has the advantage of enabling increased myocardial contractility without elevated oxygen demand or adverse reactions such as arrhythmia.