COMPOSITIONS AND USES THEREFOR

摘要

The invention is directed inter alia to the use of receptor-associated protein (RAP) polypeptide or a functional analog thereof to reduce amyloid oligomerisation and deposition and to reduce Aß associated neuropathologic features. Thus, the invention provides a composition comprising RAP or an analog thereof which binds ß-amyloid peptide (Aß) for use in the treatment or prophylaxis of a symptom of Alzheimer's disease (AD) or a related condition in a subject. One illustrative symptom is memory loss or consolidation. In another aspect, the invention provides methods of screening for RAP polypeptide functional variants or analogs by testing the ability of an agent to compete successfully with RAP for binding to Aß.