PREPARATION OF PHARMACEUTICAL SALTS OF 4[(Z)-(4-BROMOPHENYL)(ETHOXYIMINO)METHYL]-1'-[(2,4-DIMETHYL-1-OXIDO-3-PYRIDINYL)CARBONYL]-4'-METHYL-1,4'BIPIPERIDINE AS CCR5-ANTAGONIST FOR TREATMENT OF AIDS AND RELATED HIV INFECTION

摘要

<P>PROBLEM TO BE SOLVED: To prepare a pharmaceutically useful salt useful for treating AIDS and related HIV infections. Ž<P>SOLUTION: There is provided a method for preparing a mixture of rotamers or rotamer pairs of a salt of a basic compound of formula (I), wherein the mixture comprises one or more rotamers or rotamer pairs of the salt in a higher molar percentage than the corresponding rotamers or rotamer pairs of the salt, and wherein the method comprising reacting the basic compound with an acid in a mixture with a solvent. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž