发明名称 |
Methods and compositions for the prevention and treatment of anemia |
摘要 |
<p>Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.</p> |
申请公布号 |
EP1813624(B1) |
申请公布日期 |
2010.08.11 |
申请号 |
EP20070004087 |
申请日期 |
1999.10.18 |
申请人 |
AMGEN INC. |
发明人 |
EGRIE, JOAN C.;BROWNE, JEFFREY K.;ELLIOTT, STEVEN G. |
分类号 |
C07K14/505;C12N15/09;A61K38/00;A61K38/18;A61K38/22;A61K47/10;A61K47/42;A61P7/06;C12N1/15;C12N1/19;C12N5/10;C12N15/12 |
主分类号 |
C07K14/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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