发明名称 |
Immunostimulation by chemically modified single-stranded RNA |
摘要 |
Immunostimulatory agent (A) that contains at least one RNA (I) that has at least one chemical modification, is new. An independent claim is also included for a vaccine containing (A) and at least one antigen (Ag). ACTIVITY : Cytostatic; Virucide; Antibacterial; Fungicide; Protozoacide; Anti-HIV. MECHANISM OF ACTION : Vaccine; immune stimulation. (I) have a strong activating effect on antigen-presenting cells and immune cells, resulting in increased release of cytokines. Murine dendritic cells (DC) were stimulated with 10 Microg/ml of: (a) DNA 1668; or (b) RNA 1668, as phosphorothioate, for 6 days, then concentrations of interleukin (IL)-6 and -12 measured, in ng/ml. For (a) concentrations were about 23 (IL-6) and 2 (IL-12) but for (a) they were 30 and 11, respectively. 5'-UCCAUGACGUUCCUGAUGCU (RNA 1668) 5'-TCCATGACGTTCCTGATGCT (DNA 1668). |
申请公布号 |
EP2216028(A2) |
申请公布日期 |
2010.08.11 |
申请号 |
EP20100005375 |
申请日期 |
2003.07.03 |
申请人 |
CUREVAC GMBH |
发明人 |
HOERR, INGMAR, DR.;PASCOLO, STEVE, DR.;VON DER MÜLBE, FLORIAN |
分类号 |
A61K31/7115;A61K31/7125;A61K35/66;A61K39/00;A61K39/39;A61P37/04;C12N15/117 |
主分类号 |
A61K31/7115 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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