发明名称 |
CONSTRUCT SYSTEM AND USES THEREFOR |
摘要 |
The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response results from the expression of a polynucleotide that encodes at least a portion of the target antigen, wherein the quality is modulated by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower preference of usage by the mammal to confer the immune response than the codon it replaces. |
申请公布号 |
EP2215269(A1) |
申请公布日期 |
2010.08.11 |
申请号 |
EP20080800100 |
申请日期 |
2008.10.02 |
申请人 |
THE UNIVERSITY OF QUEENSLAND |
发明人 |
FRAZER, IAN HECTOR;DUTTON, JULIE |
分类号 |
C12N15/11 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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