发明名称 |
REDUCTION AND PREVENTION OF CELL-ASSOCIATED HIV TRANSEPITHELIAL MIGRATION, MICROBIDES AND OTHER FORMULATIONS AND METHODS |
摘要 |
<p>A vaginal microbicide including scFv-type antibodies reduces or prevents transepithelial HIV transmission. As the antibodies, anti-CD 18 and/or anti-CD 11 antibodies (of the scFv type) are used. Preferably, anti-ICAM antibody also is used. The antibodies may be delivered to the to-be-protected epithelium using a bacterial delivery system such as a lactobacillus bacterial vehicle. HIV transepithelial transmission can thereby be reduced or prevented, including prevention of initial infection.</p> |
申请公布号 |
EP1951306(A4) |
申请公布日期 |
2010.08.11 |
申请号 |
EP20060816987 |
申请日期 |
2006.10.13 |
申请人 |
THE JOHNS HOPKINS SCHOOL OF MEDICINE |
发明人 |
MARKHAM, RICHARD |
分类号 |
A61K39/42;A01N63/00;A61K48/00;A61P31/18 |
主分类号 |
A61K39/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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