A SUCCESSIVE PREPARATION METHOD OF 3-ISOTHIAZOLONE DERIVATES AND THEIR INTERMEDIATES

摘要

The present application provides a process for continuously producing 3-isothiazolinone derivatives and intermediate products thereof, comprising continuously carrying out four steps, i.e ., sulfuration, purification, amination and chlorination. Compared with the batch process of the prior art, the process of the present application may reduce the amount of manufacturing devices, lower energy consumption, simplify operations, and is therefore particularly suitable for mass production.