发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF INSULIN RESISTANCE |
摘要 |
<p>Disclosed herein are methods of delaying the onset or treating diabetes that comprises administering a uric acid lowering agent. The inventors have made the remarkable discovery that elevated uric acid levels are not a corollary to insulin resistance, but rather a primary mediator of insulin resistance. Specifically exemplified are methods that involve administering to a patient susceptible to development of diabetes a composition comprising a uric acid lowering agent in a regimen that maintains serum uric acid levels below at least 5.2 to 5.5 mg/dl.</p> |
申请公布号 |
EP1778261(A4) |
申请公布日期 |
2010.08.11 |
申请号 |
EP20050780481 |
申请日期 |
2005.07.21 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
JOHNSON, RICHARD, J.;NAKAGAWA, TAKAHIKO |
分类号 |
A61K36/18;A61K31/00;A61K31/426;A61K31/4439;A61P3/10 |
主分类号 |
A61K36/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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