发明名称 |
VERTEBRATE APOPTOSIS GENE: COMPOSITIONS AND METHODS |
摘要 |
The invention relates generally to compositions of and methods for obtain-ing and using a polypeptide other than BCL-2 (SEQ ID NO.5) that affects pro-grammed vertebrate cell death. The in-vention relates as well to polynucleotides encoding those polypeptides, recombi-nant vectors carrying those sequences, the recombinant host cells including ei-ther the sequences or vectors, and re-combinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in as says designed to select and improve sub-stances capable of altering programmed cell death for use in diagnostic, drug de-sign and therapeutic applications.
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申请公布号 |
CA2165969(C) |
申请公布日期 |
2010.08.10 |
申请号 |
CA19942165969 |
申请日期 |
1994.06.22 |
申请人 |
ARCH DEVELOPMENT CORPORATION;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
THOMPSON, CRAIG B.;BOISE, LAWRENCE H.;NUNEZ, GABRIEL |
分类号 |
C12N15/12;G01N33/53;A61K38/00;A61K38/17;A61K39/395;A61K48/00;A61P35/00;A61P43/00;C07K14/435;C07K14/465;C07K14/47;C07K16/18;C12N5/00;C12N5/10;C12N15/09;C12P21/02;C12Q1/00;C12Q1/68;C12R1/91 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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