MODIFIED PEPTIDE YY AND CONJUGATE THEREOF

摘要

<P>PROBLEM TO BE SOLVED: To provide a therapeutic method using a modified peptide by modifying a therapeutic peptide so as to protect the same from peptidase activity, offer longer duration of activity in-vivo and keep its toxicity low. Ž<P>SOLUTION: The modified therapeutic peptide is formable of a therapeutic peptide conjugate stabilized against peptidase activity, provided that the peptide includes a carboxy-terminal amino acid, an amino-terminal amino acid, a therapeutically active domain and a lowly therapeutically active domain identified through structure-activity analysis. The peptide contains a specific amino acid sequence having a reactive group that binds to an amino acid located within the lowly therapeutically active domain of the amino acid. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž