发明名称 |
PROCESS FOR THE ENANTIOSELECTIVE PREPARATION OF PREGABALIN |
摘要 |
The invention provides a new enantioselective process for the preparation of (S)-pregabalin, or a pharmaceutical acceptable addition acid salt comprising: acid hydrolysis of the dioxolan ring of a chiral compound of general formula (I) to obtain compound of general formula (II); oxidation of compound (II) to obtain a compound of general formula (III) and transforming compound (III) into compound of general formula (IV); subjecting compound (IV) to basic hydrolysis to obtain a compound of general formula (V) which is reduced to obtain enantiomerically pure S-pregabalin. The invention also provides new chiral intermediates involved in the process.
|
申请公布号 |
US2010197939(A1) |
申请公布日期 |
2010.08.05 |
申请号 |
US20080669517 |
申请日期 |
2008.07.17 |
申请人 |
LABORATORIOS DEL DR. ESTEVE, S.A. |
发明人 |
ORTUNO ROSA M.;IZQUIERDO SANDRA;HEINRICH BUSCHMANN HELMUT;TORRENS JOVER ANTONI;GARCIA LOPEZ MONICA |
分类号 |
C07D405/04;C07C227/32;C07C271/22;C07D207/26;C07D207/27 |
主分类号 |
C07D405/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|