摘要 |
The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBI2) and cholest-5-ene-3b,7b,25-triol(7, 25- dihydroxycholesterol)(''7,25DHC'') and/orcholest-5-ene-3b, 7b-diol(7- hydroxycholesterol)(''7HC'') 25-diol (25-hydroxycholesterol)(''25HC''), especially the cholest-5-ene-3b,7a,25-triol(7a, 25-dihydroxycholesterol)(''7a,25DHC'')and/or cholest-5-ene-3b,7b,25-triol(7b, 25-dihydroxycholesterol)(''7b,25DHC'') stereoisomers. The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described. |
申请人 |
NOVARTIS AG;THE SCRIPPS RESEARCH INSTITUTE;IRM LLC;BAUMGARTEN, BIRGIT;GESSIER, FRANCOIS;KATOPODIS, ANDREAS;KNOCHENMUSS, RICHARD;FALCHETTO, ROCCO;ROGGO, SILVIO;SAILER, ANDREAS;SEUWEN, KLAUS;SPANKA, CARSTEN;ZHANG, JUAN;HANNEDOUCHE, SEBASTIEN;NOEL, SOPHIE;ROY, MARIE-ODILE;CHEN, YU;CHO, CHARLES Y.;LI, WEI;SHEN, WEIJUN |
发明人 |
BAUMGARTEN, BIRGIT;GESSIER, FRANCOIS;KATOPODIS, ANDREAS;KNOCHENMUSS, RICHARD;FALCHETTO, ROCCO;ROGGO, SILVIO;SAILER, ANDREAS;SEUWEN, KLAUS;SPANKA, CARSTEN;ZHANG, JUAN;HANNEDOUCHE, SEBASTIEN;NOEL, SOPHIE;ROY, MARIE-ODILE;CHEN, YU;CHO, CHARLES Y.;LI, WEI;SHEN, WEIJUN |