发明名称 |
KEY INTERMEDIATES FOR THE SYNTHESIS OF ROSUVASTATIN OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
摘要 |
The present invention relates in general to the field of organic chemistry and in particular to the preparation of N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N- methylmethanesulfonamide (I), N-(4-(4-fluorophenyl)-5-(bromomethyl)-6-isopropylpyrimidin-2- yl)-N-methylmethanesulfonamide (II) and N-(4-(4-fluorophenyl)-5-(hydroxymethyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (III), key intermediates in preparation of Rosuvastatin. |
申请公布号 |
WO2010086438(A1) |
申请公布日期 |
2010.08.05 |
申请号 |
WO2010EP51163 |
申请日期 |
2010.02.01 |
申请人 |
LEK PHARMACEUTICALS D.D.;CASAR, ZDENKO;KOSMRLJ, JANEZ |
发明人 |
CASAR, ZDENKO;KOSMRLJ, JANEZ |
分类号 |
C07D239/42;A61K31/505;A61P3/06 |
主分类号 |
C07D239/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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