发明名称 |
EOTAXIN-2 (CCL24) INHIBITORS IN INFLAMMATORY, AUTOIMMUNE, AND CARDIOVASCULAR DISORDERS |
摘要 |
The present invention is based on the finding that inhibition of eotaxin-2 by polyclonal or monoclonal antibodies, has a significant protective effect in animal models of inflammatory diseases such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), colitis, diabetes, and atherosclerosis. The invention thus provides pharmaceutical compositions comprising specific anti-eotaxin 2 antibodies for use alone or in combination with other therapeutic agents in the treatment of inflammatory, autoimmune and cardiovascular diseases. The invention also provides specific anti-eotaxin-2 monoclonal antibodies, and methods of treatment utilizing the antibodies of the invention. |
申请公布号 |
WO2010086854(A1) |
申请公布日期 |
2010.08.05 |
申请号 |
WO2010IL00073 |
申请日期 |
2010.01.28 |
申请人 |
THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER;GEORGE, JACOB;KEREN, GAD |
发明人 |
GEORGE, JACOB;KEREN, GAD |
分类号 |
C07K16/24;A61K39/00;C07K14/52 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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